Interdisziplinären Veranstaltung der Fachbereich Biologie, Molekulare Medizin und Humanmedizin im Rahmen des Studieninformationstags Baden-Württemberg 20.11.2024 im ZTZ Freiburg.

Wissenschaftler*innen und Ärzt*innen des Sonderforschungsbereichs 1479 der Uniklinik Freiburg erklären, wie bestimmte genetische Eigenschaften zur Entstehung von Tumorzellen beitragen und welche Möglichkeiten es gibt, das Immunsystem bei seinem Kampf gegen die Krebszellen zu unterstützen. Professoren und Studenten der drei Fachbereiche beantworten gerne Fragen zum Studium der Biologie, Medizin und der Molekularen Medizin an der Universität Freiburg, sowie zu den aktuellen Themen der Krebsforschung am Uniklinikum Freiburg.

Programm 

 08:30 Uhr         Begrüßung und Vorstellung

Prof. Dr. Tilman Brummer (Cosprecher SFB1479)

Institut für Molekulare Medizin und Zellforschung Albert-Ludwigs-Universität Freiburg

08:40 Uhr         Warum entsteht Krebs?         

Prof. Dr. Tilman Brummer

09:00 Uhr         Zelluläre Superhelden: Wie CAR-T-Zellen Krebs bekämpfen

Prof. Dr. Susana Minguet (Teilprojektleiterin SFB1479)

Fakultät für Biologie Albert-Ludwigs-Universität Freiburg

09.15 Uhr         Welche Medikamente machen Krebszellen sichtbar für das Immunsystem?

Dr. Nguyen Huong Jenny Giang Ho (Gerokstelle SFB1479)

Ärztin Abteilung für Tumorimmunologie und Immunregulation, Universitätsklinikum Freiburg

09.30 Uhr         Krebsforschung im Mikromaßstab: Wie uns Einzelzell-RNA-Sequenzierung hilft, das Zusammenspiel von Tumor und Immunsystem besser zu verstehen

Melissa Zwick (Doktorandin SFB1479)

PHD-Studentin Molekulare Medizin

09.45 Uhr         offene Fragerunde

From the 7^th to the 10^th of October 2024, the IRTG 1479 retreat took place in Paris. It was a great opportunity for our PhD and MD students to discuss their projects, promote networking and allow personal exchange.

The students visited the Curie Institute, known worldwide for its renowned cancer research unit. They had the chance to connect with leading scientists of this field and got to meet different research groups. It was a great opportunity to connect to the student of the Curie Institute as well. This exchange can serve as a basis for future collaborations and expand the scientific network.

From the 16^th to the 18^th of October 2023, the IRTG 1479 retreat took place in Amsterdam. It was a great opportunity for our PhD and MD students to discuss their projects, promote networking and allow personal exchange.

Additionally the students visited the Netherlands Cancer Institute and the group of Hein Te Riele. Here they had the chance to hear a scientific lecture from Leila Akkari and got to meet different research groups. It was a great opportunity to connect to the student council members of the Netherlands Cancer Instituteas as well.

The CRC1479 Symposium “Oncogene driven immune escape” will take place on July 10^th till 12^th , 2024 in the University Building KG1, Freiburg (Germany).

This Symposium will give you the opportunity to debate the current concepts of oncogenic signaling and immune escape mechanisms at the beautiful venue of the old University Building (KG1) in Freiburg. We invite you to share your knowledge in scientific discussions to exchange thoughts and ideas.

From the organizers  Robert Zeiser and Tilman Brummer

OncoEscape researchers Prof. Ian Frew and Prof. Melanie Börries, together with Prof. Marc Timmers, Prof. Christian Gratzke and Prof. Roland Schüle from Freiburg, as well as colleagues from the Uniklinik Aachen and Uniklinik Tübingen have received 4,3 million Euros from the DFG to establish the UcarE (Urothelial Carcinoma Epigenetics) Research Unit. This new research network will investigate the effects of mutations of epigenetic regulatory genes on the formation and progression of bladder cancer and seeks to identify new therapeutic targets for aggressive urothelial carcinomas. The bladder cancer research efforts of UcarE will generate new research synergies with OncoEscape.

On 12th and 13th of July 2023 the second retreat of the CRC1479 took place in Freiburg.

It was a great opportunity to meet again in the ZTZ Freiburg and deepen the collaborations. In the evening, we enjoyed scientific discussion in the nice atmosphere of the black forest location St. Ottilien.

With the help of the CRC1479 Junior Fellowship the CRC 1479 would like to promote young scientists at the level of junior group leader, who work in the fields of oncogenic signalling and tumour immune escape. The CRC1479 Junior Fellowship will include 50.000 Euro funding. The money will be spent for experiments to develop into the topic of the CRC1479.

After a competitive application process, we are pleased to welcome Dr. Natascha Röhlen and Dr. Sebastian Halbach as awardee and associate members of the CRC1479.

Congratulations!

Symposium “Advances in Stem Cell Transplantation and Cell Therapy 2023” in honor of Prof Jürgen Finke

Advances in Stem Cell Transplantation and Cell Therapy 2023 | Universitätsklinikum Freiburg (uniklinik-freiburg.de)

It was in 1989 that the first patients underwent allogeneic marrow transplants in Freiburg. The field of hematopoietic cell transplantation has developed remarkably since then, allowing for transplantation of elderly patients and achieving higher cure rates due to improvements in many areas, such as novel graft­versus-host disease prevention and treatment strategies, post allo-HCT maintenance therapy and approaches to enhance the graft-versus-leukemia effect.

In honor of Prof Jürgen Finke, who has developed allogeneic stem cell transplantation in the Department of Hematology and Oncology at Freiburg University Medical Center, we have invited experts for an international symposium covering the major topics raised by recent developments in the field. These will cover the role of the intestinal microbiome and the intestinal immune system in GVHD, tissue-regenerative approaches for acute GVHD, chronic GVHD biology and treatment, basic mechanisms of leukemia immune evasion, novel CAR T cell and engineered NK cell products. This event will give you the opportunity to debate the current concepts of Stem Cell Transplantation and Cell Therapy at the beautiful venue of the Historische Kaufhaus in Freiburg.

We invite you to share your knowledge in discussions covering science, exchanging thoughts and ideas, and seeing old friends and making new ones.

From the organizers

Robert Zeiser   Justus Duyster

Dr. Susana Minguet García erhält zum 1. April 2023 eine Heisenberg-Professur der Deutschen Forschungsgemeinschaft (DFG) für Synthetische Immunologie. Zusätzlich fördert die DFG ihre Forschungen zum Verständnis der Aktivierung von T-Zellen. Die Ergebnisse will Minguet García nutzen, um neue Immuntherapien gegen Krebs sowie Behandlungsmöglichkeiten von Autoimmunerkrankungen und weiteren Erkrankungen des Immunsystems zu entwickeln.

Heisenberg-Professur für Susana Minguet García

Mit einem ERC Advanced Grant fördert der Europäische Forschungsrat Prof. Dr. Robert Zeiser. Robert Zeiser erforscht mit seinem Team neue Ansatzpunkte, um die Heilung von Patient*innen nach einer Stammzelltransplantation zu verbessern. Ziel ist es durch neue, zielgerichtete Therapien schwere Komplikationen nach einer Stammzelltransplantation zu verhindern.

Große EU-Förderung soll Leukämie-Therapien sicherer machen | Universitätsklinikum Freiburg (uniklinik-freiburg.de)