Principal Investigator

Department of Hematology, Oncology and Stem-Cell Transplantation
Medical Center University of Freiburg

Breisacher Str. 115
79106 Freiburg

Current position

Full Professor (W3) for Oncogenic Signaling, Internal Medicine I, Hematology and Oncology, Medical Center University of Freiburg

Academic training

1994 - 1997Bachelor of Science, Honours (Molecular Biology and Biochemistry), Australian National University, Canberra, Australia

Advanced academic qualifications

2003PhD, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia

Postgraduate positions

Since 2017Full Professor (W3), Medical Center University of Freiburg
2010 - 2016Assistant Professorship of the Swiss National Science Foundation
2010 - 2016Assistant Professorship of the Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
2003 - 2009Postdoctoral research fellow, Institute of Cell Biology, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland
1998 - 2003PhD, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia

Miscellaneous (Honors, Awards)

2010 - 2016Swiss National Science Foundation Professorship
2010 - 2015European Research Council Starting Grant
2003 - 2005Serono Foundation for the Advancement of Medical Science Postdoctoral Fellowship in Cancer Biology
2003Peter MacCallum Cancer Centre Postgraduate Research Medal
1998 - 2002Sir Russell Grimwade PhD scholarship, University of Melbourne
1997University Medal in Biochemistry and Molecular Biology, Australian National University

Publications listed in PubMed®

Publications (based on CRC1479 funding)

Catalano A, Haas LS, Zodel K, Adlesic M, Cuomo F, Peighambari A, Metzger P, Huang H, Haug S, Köttgen A, Köhler N, Boerries M, Frew IJ. Mutations in tumor suppressor genes Vhl and Rassf1a cause DNA damage, chromosomal instability and induce gene expression changes characteristic of clear cell renal cell carcinoma. Kidney Int. 2024 Dec 24:S0085-2538(24)00912-8. doi: 10.1016/j.kint.2024.12.003. Epub ahead of print.

Mohl DA, Lagies S, Zodel K, Zumkeller M, Peighambari A, Ganner A, Plattner DA, Neumann-Haefelin E, Adlesic M, Frew IJ, Kammerer B. Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma. Cells. 2023 Apr 7;12(8):1102. doi: 10.3390/cells12081102.

Seidel P, Rubarth A, Zodel K, Peighambari A, Neumann F, Federkiel Y, Huang H, Hoefflin R, Adlesic M, Witt C, Hoffmann DJ, Metzger P, Lindemann RK, Zenke FT, Schell C, Boerries M, von Elverfeldt D, Reichardt W, Follo M, Albers J, Frew IJ. ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma. JCI Insight. 2022 Dec 22;7(24):e156087. doi: 10.1172/jci.insight.156087. PMID: 36413415; PMCID: PMC9869969.

Hoefflin R, Harlander S, Abhari BA, Peighambari A, Adlesic M, Seidel P, Zodel K, Haug S, Göcmen B, Li Y, Lahrmann B, Grabe N, Heide D, Boerries M, Köttgen A, Heikenwalder M, Frew. Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma. Cancers (Basel). 2021 Sep 25;13(19):4801. doi: 10.3390/cancers13194801.