Katrin Kierdorf

Principal Investigator

Institute of Neuropathology
Medical Faculty, University of Freiburg

Breisacher Straße 64
79106 Freiburg

Current position

Juniorprofessor (W1) for Neuroimmunology, Institute of Neuropathology, Medical Center University of Freiburg

Academic training

2004 – 2008Diploma Studies in Molecular Biomedicine, University of Bonn,
Academic degree: Diploma in Molecular Biomedicine (Dipl. Mol. Biomed.)

Advanced academic qualifications

2013Doctorate, Doctor rerum naturalium (Dr. rer. nat.), summa cum laude

Postgraduate positions

Since 2017Juniorprofessor for Neuroimmunology, Institute of Neuropathology, Medical Faculty, University of Freiburg
2015 - 2017Research Associate at the MRC Centre for Molecular Bacteriology and Infection, Imperial College London, United Kingdom
2013 - 2015Research Associate at the Centre for Molecular and Cellular Biology of Inflammation, King’s College London, United Kingdom
2013Research Associate at the Institute of Neuropathology, Medical Center University of Freiburg
2008 - 2013PhD student at the Institute of Neuropathology, University of Freiburg

Miscellaneous (Honors, Awards)

2014 - 2016Postdoctoral Fellowship of the German Research Foundation (DFG)
2014Award of the Society „Gesellschaft zur Förderung der Immunologie in Freiburg und zum Andenken an Georges Köhler e. V.“
2013Herbert-Fischer-Award of the German Society of Immunology (Dgfi)

Publications listed in PubMed®

Publications (based on CRC1479 funding)

Saller BS, Wöhrle S, Fischer L, Dufossez C, Ingerl IL, Kessler S, Mateo-Tortola M, Gorka O, Lange F, Cheng Y, Neuwirt E, Marada A, Koentges C, Urban C, Aktories P, Reuther P, Giese S, Kirschnek S, Mayer C, Pilic J, Falquez-Medina H, Oelgeklaus A, Deepagan VG, Shojaee F, Zimmermann JA, Weber D, Tai YH, Crois A, Ciminski K, Peyronnet R, Brandenburg KS, Wu G, Baumeister R, Heimbucher T, Rizzi M, Riedel D, Helmstädter M, Buescher J, Neumann K, Misgeld T, Kerschensteiner M, Walentek P, Kreutz C, Maurer U, Rambold AS, Vince JE, Edlich F, Malli R, Häcker G, Kierdorf K, Meisinger C, Köttgen A, Jakobs S, Weber ANR, Schwemmle M, Groß CJ, Groß O. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2024 Nov 15:S1074-7613(24)00492-8. doi: 10.1016/j.immuni.2024.10.012. Epub ahead of print. Vinnakota JM, Biavasco F, Schwabenland M, Chhatbar C, Adams RC, Erny D, Duquesne S, El Khawanky N, Schmidt D, Fetsch V, Zähringer A, Salié H, Athanassopoulos D, Braun LM, Javorniczky NR, Ho JNHG, Kierdorf K, Marks R, Wäsch R, Simonetta F, Andrieux G, Pfeifer D, Monaco G, Capitini C, Fry TJ, Blank T, Blazar BR, Wagner E, Theobald M, Sommer C, Stelljes M, Reicherts C, Jeibmann A, Schittenhelm J, Monoranu CM, Rosenwald A, Kortüm M, Rasche L, Einsele H, Meyer PT, Brumberg J, Völkl S, Mackensen A, Coras R, von Bergwelt-Baildon M, Albert NL, Bartos LM, Brendel M, Holzgreve A, Mack M, Boerries M, Mackall CL, Duyster J, Henneke P, Priller J, Köhler N, Strübing F, Bengsch B, Ruella M, Subklewe M, von Baumgarten L, Gill S, Prinz M, Zeiser R. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nat Cancer. 2024 May 13. doi: 10.1038/s43018-024-00764-7. Epub ahead of print.

Petry P, Oschwald A, Kierdorf K. Microglial tissue surveillance: The never-resting gardener in the developing and adult CNS. Eur J Immunol. 2023 Jul;53(7):e2250232. doi: 10.1002/eji.202250232. Epub 2023 May 5.

 

Mass E, Nimmerjahn F, Kierdorf K, Schlitzer A. Tissue-specific macrophages: how they develop and choreograph tissue biology. Nat Rev Immunol. 2023 Mar 15:1–17. doi: 10.1038/s41577-023-00848-y. Epub ahead of print.

Aktories P, Petry P, Glatz P, Andrieux G, Oschwald A, Botterer H, Gorka O, Erny D, Boerries M, Henneke P, Groß O, Prinz M, Kierdorf K. An improved organotypic cell culture system to study tissue-resident macrophages ex vivo. Cell Rep Methods. 2022 Jul 26;2(8):100260. doi: 10.1016/j.crmeth.2022.100260.

Bosch LFP, Kierdorf K. The Shape of μ-How Morphological Analyses Shape the Study of Microglia. Front Cell Neurosci. 2022 Jun 29;16:942462. doi: 10.3389/fncel.2022.942462.

Aktories P, Petry P, Kierdorf K. Microglia in a Dish-Which Techniques Are on the Menu for Functional Studies? Front Cell Neurosci. 2022 Jun 3;16:908315. doi: 10.3389/fncel.2022.908315.

Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M. Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 Apr;604(7907):740-748. doi: 10.1038/s41586-022-04596-2. Epub 2022 Apr 20. Erratum in: Nature. 2022 Oct;610(7930):E1.