Maike Hofmann

Principal Investigator

Department of Medicine II
Gastroenterology, Hepatology, Endocrinology and Infectious Diseases
Medical Center University of Freiburg

Hugstetter Straße 55
79106 Freiburg

Current position

Group Leader, Liver Immunology Lab, Department of Medicine II, Medical Center University of Freiburg

Academic training

02/07 - 10/07Diploma thesis, Molecular Medicine, Institute of Immunology, Medical Center University of Freiburg
2002 - 2007Studies in Molecular Medicine, University of Freiburg

Advanced academic qualifications

2012PhD, Molecular Medicine / Immunology, Institute of Immunology, Medical Center University of Freiburg

Postgraduate positions

Since 2016Group Leader, Department of Medicine II - Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center University of Freiburg
Since 2014Senior Scientist, Department of Medicine II - Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center University of Freiburg
03/14 - 07/14Postdoc, University spin-off cytena / Department for Microsystems Engineering, University of Freiburg
2012 - 2014Postdoc, Institute of Immunology, Medical Center University of Freiburg
2007 - 2012PhD thesis, Molecular Medicine / Immunology, Institute of Immunology, Medical Center University of Freiburg

Miscellaneous (Honors, Awards)

2021Adolf Kussmaul Prize
Since 2019Margarete von Wrangell-Fellowship
2017DZIF Maternity Leave Stipend

Publications listed in PubMed®

Publications (based on CRC1479 funding)

Zhang Z, Langenbach M, Sagar S, Fetsch V, Stritzker J, Severa E, Meng K, Winkler F, Rana N, Zoldan K, Godbole I, Solis S, Weber JS, Rafei-Shamsabadi D, Lehr S, Diehl R, Venhoff AC, Voll RE, Buettner N, Neumann-Haefelin C, Boettler T, Hofmann M, Boerries M, Meiss F, Zeiser R, Thimme R, Herati RS, Bengsch B. Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells. Nat Immunol. 2024 Dec 19. doi: 10.1038/s41590-024-02027-0. Epub ahead of print.
Kotsiliti E, Leone V, Schuehle S, Govaere O, Li H, Wolf MJ, Horvatic H, Bierwirth S, Hundertmark J, Inverso D, Zizmare L, Sarusi-Portuguez A, Gupta R, O’Connor T, Giannou AD, Shiri AM, Schlesinger Y, Beccaria MG, Rennert C, Pfister D, Öllinger R, Gadjalova I, Ramadori P, Rahbari M, Rahbari N, Healy ME, Fernández-Vaquero M, Yahoo N, Janzen J, Singh I, Fan C, Liu X, Rau M, Feuchtenberger M, Schwaneck E, Wallace SJ, Cockell S, Wilson-Kanamori J, Ramachandran P, Kho C, Kendall TJ, Leblond AL, Keppler SJ, Bielecki P, Steiger K, Hofmann M, Rippe K, Zitzelsberger H, Weber A, Malek N, Luedde T, Vucur M, Augustin HG, Flavell R, Parnas O, Rad R, Pabst O, Henderson NC, Huber S, Macpherson A, Knolle P, Claassen M, Geier A, Trautwein C, Unger K, Elinav E, Waisman A, Abdullah Z, Haller D, Tacke F, Anstee QM, Heikenwalder M. Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling. J Hepatol. 2023 Aug;79(2):296-313. doi: 10.1016/j.jhep.2023.04.037. Epub 2023 May 22.

Raute K, Strietz J, Parigiani MA, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet S. Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands. Cancer Immunol Res. 2023 May 4:OF1-OF20. doi: 10.1158/2326-6066. CIR-22-0296. Epub ahead of print.

Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D’Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B. T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma. J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. Epub 2022 Apr 1.