Mathias Heikenwälder
Principal Investigator
Department Chronic Inflammation and Cancer
German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 242
69120 Heidelberg
- +49 6221 42-3890
- m.heikenwaelder@dkfz.de
- Homepage
Current position
Academic training
| 1999 - 2001 | Diploma student in Molecular Biology at Max-Delbrück Center for Molecular Medicine (MDC), Berlin |
| 1995 - 1999 | Studies of Microbiology and Genetics at University of Vienna, the Vienna Biocenter (VBC) and the Institute of Molecular Pathology (IMP), Vienna, Austria |
Advanced academic qualifications
| 2009 | Habilitation: ‘Experimental Pathology’ at the Medical Faculty, University of Zurich, Switzerland |
| 2004 | PhD, Institute of Neuropathology, University Hospital Zurich (USZ)/ Eidgenössische Technische Hochschule (ETH), Zurich, Switzerland |
Postgraduate positions
| Snce 2015 | W3-Professor, Medical Faculty, University Heidelberg and DKFZ |
| Since 2013 | Certified “Science Manager”, Malik Management School, St. Gallen, Switzerland and Helmholtz academy for leadership, Germany |
| 2010 - 2015 | Gruppenleiter und Helmholtz Young Investigator an der Technischen Universität München (TUM)/ Helmholtz-Zentrum München, Institut für Virologie und (W2) Professor |
| 2007 - 2008 | Prof. Dr. Max Cloëtta fellow und unabhängiger Gruppenleiter in der Abteilung Pathologie sowie principal investigator (PI) |
| 2006 - 2007 | Wissenschaftlicher Mitarbeiter und Dozent in der Abteilung Pathologie, Institut für Neuropathologie |
| 2004 - 2010 | Postdoctoral fellow am Institut für Neuropathologie, Abteilung Pathologie, Universitätsspital Zürich (USZ), Schweiz |
| 2001 - 2004 | PhD student at the Institute of Neuropathology, University Hospital Zurich (USZ)/ Eidgenössische Technische Hochschule (ETH), Zurich, Switzerland |
Miscellaneous (Honors, Awards)
| Since 2019 | Member in the SAB for PSC MAYO Clinic, USA |
| 2019 | Elected Member of the Leopoldina, Nationale Akademie der Wissenschaften |
| 2018 | Swiss liver Prize of the Gastroenterology society 2018 |
| Since 2015 | Director of the Cancer Inflammation program at DKFZ together with the NIH |
| 2015 | Awarded with an ERC Consolidator Grant on the topic of ‘HepatoMetaboPath’ (EU) |
| 2013 | Walther and Christine Richtzenhain Prize for ‘Translation Research in Cancer’ |
| 2012 | Peter-Hans Hofschneider Award for ‘Research in Gastroenterology’ |
| 2010 | Awarded with an ERC Starting Grant on ‘Liver cancer mechanism’ (EU) |
| 2009 | Götz Prize for ‘Investigating the role of chronic inflammation in disease’ |
| 2007 | Prof. Dr, Max Cloëtta Award for ‘Neuroinflammation Research’ |
| 2006 | Empiris Award for Brain Research |
| 2004 | Science Creutzfeldt-Prize for ‘Advances in Prion Research’ |
| 2004 | Scientific-Award of the University Zurich, Switzerland |
| 1999 | ERASMUS-fellowship provided by the European Community |
Publications listed in PubMed®
Publications (based on CRC1479 funding)
Kotsiliti E, Leone V, Schuehle S, Govaere O, Li H, Wolf MJ, Horvatic H, Bierwirth S, Hundertmark J, Inverso D, Zizmare L, Sarusi-Portuguez A, Gupta R, O’Connor T, Giannou AD, Shiri AM, Schlesinger Y, Beccaria MG, Rennert C, Pfister D, Öllinger R, Gadjalova I, Ramadori P, Rahbari M, Rahbari N, Healy ME, Fernández-Vaquero M, Yahoo N, Janzen J, Singh I, Fan C, Liu X, Rau M, Feuchtenberger M, Schwaneck E, Wallace SJ, Cockell S, Wilson-Kanamori J, Ramachandran P, Kho C, Kendall TJ, Leblond AL, Keppler SJ, Bielecki P, Steiger K, Hofmann M, Rippe K, Zitzelsberger H, Weber A, Malek N, Luedde T, Vucur M, Augustin HG, Flavell R, Parnas O, Rad R, Pabst O, Henderson NC, Huber S, Macpherson A, Knolle P, Claassen M, Geier A, Trautwein C, Unger K, Elinav E, Waisman A, Abdullah Z, Haller D, Tacke F, Anstee QM, Heikenwalder M. Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling. J Hepatol. 2023 Aug;79(2):296-313. doi: 10.1016/j.jhep.2023.04.037. Epub 2023 May 22.
Hoefflin R, Harlander S, Abhari BA, Peighambari A, Adlesic M, Seidel P, Zodel K, Haug S, Göcmen B, Li Y, Lahrmann B, Grabe N, Heide D, Boerries M, Köttgen A, Heikenwalder M, Frew. Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma. Cancers (Basel). 2021 Sep 25;13(19):4801. doi: 10.3390/cancers13194801.
Li X, Ramadori P, Pfister D, Seehawer M, Zender L, Heikenwalder M. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer. 2021 Sep;21(9):541-557. doi: 10.1038/s41568-021-00383-9.
Contact
