Nina Cabezas-Wallscheid

Principal Investigator

Max Planck Institute of Immunobiology and Epigenetics (MPI-IE)

Stübeweg 51
79108 Freiburg

Current position

Group leader MPI-IE, Freiburg
Additional affiliation: Principal Investigator, Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg

Academic training

2000 - 2005MSc Biotechnology, University of Barcelona, Spain and University of Parma, Italy

Advanced academic qualifications

2010PhD, Laboratory of Molecular Mouse Genetics, Div. of Exp. and Translational Oncology, Medical Center of the Johannes Gutenberg University of Mainz

Postgraduate Positions

Since 2017Group Leader, MPI-IE, Freiburg
2011 - 2017Postdoctoral fellow, Dept. of Stem Cells and Cancer, DKFZ, HI-STEM, Heidelberg
05/10 - 12/10Postdoctoral bridge, Division of Exp. and Translational Oncology, Medical Center of the Johannes Gutenberg University of Mainz
09-10/08Guest Scientist, Harvard Dept. of Stem Cell and Regenerative Biology, Boston, USA
2006 - 2010PhD, Laboratory of Molecular Mouse Genetics, Division of Exp. and Translational Oncology, Medical Center of the Johannes Gutenberg University of Mainz

Miscellaneous (Honors, Awards)

2019Josep Carreras Foundation Grant
2019Visiting Assistant Professor Kumamoto University, Japan
2018Behrens Weise Foundation
2018Centre for Integrative Biological Signaling Studies (CIBSS) Excellence Cluster, University of Freiburg
2018Marie Skłodowska-Curie Actions- Innovative Training Networks (MSCA-INT)
2018Young Investigator Award, German Stem Cell Network (GSCN), Germany
2018ERC Starting Grant, Freiburg, Germany
2016New Investigator Postdoctoral Fellow Award, International Society Experimental Hematology (ISEH), San Diego, USA
2015Young Investigator Fund NicHem; DFG Unit For 2033, Heidelberg, Germany
2008Boehringer Ingelheim Foundation Travel Fellowship, Harvard Stem Cell Institute, Boston, USA
2007PhD Fellowship, Mainzer Forschungsfond (MAIFOR), University of Mainz, Germany

Publications listed in PubMed®

Publications (based on CRC1479 funding)

Talvard-Balland N, Braun LM, Dixon KO, Zwick M, Engel H, Hartmann A, Duquesne S, Penter L, Andrieux G, Rindlisbacher LS, Acerbis A, Ehmann J, Köllerer C, Ansuinelli M, Rettig A, Moschallski K, Apostolova P, Brummer T, Illert AL, Schramm MA, Cheng Y, Köttgen A, Duyster J, Menssen HD, Ritz J, Blazar BR, Boerries M, Schmitt Graeff A, Sariipek N, van Galen P, Buescher JM, Cabezas-Wallscheid N, Pahl HL, Pearce EL, Soiffer RJ, Wu CJ, Vago L, Becher B, Köhler N, Wertheimer T, Kuchroo VK, Zeiser R. Oncogene induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice. J Clin Invest. 2024 Jun 25:e177460. doi: 10.1172/JCI177460. Epub ahead of print.

Schaffer AM, Fiala GJ, Hils M, Natali E, Babrak L, Herr LA, Romero-Mulero MC, Cabezas-Wallscheid N, Rizzi M, Miho E, Schamel WWA, Minguet S. Kidins220 regulates the development of B cells bearing the λ light chain. Elife. 2024 Jan 25;13:e83943. doi: 10.7554/eLife.83943.

Villa M, Sanin DE, Apostolova P, Corrado M, Kabat AM, Cristinzio C, Regina A, Carrizo GE, Rana N, Stanczak MA, Baixauli F, Grzes KM, Cupovic J, Solagna F, Hackl A, Globig AM, Hässler F, Puleston DJ, Kelly B, Cabezas-Wallscheid N, Hasselblatt P, Bengsch B, Zeiser R, Sagar, Buescher JM, Pearce EJ, Pearce EL. Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment. Nat Commun. 2024 Jan 11;15(1):451. doi: 10.1038/s41467-024-44689-2.

Ho JNHG, Schmidt D, Lowinus T, Ryoo J, Dopfer EP, Gonzalo Núñez N, Costa-Pereira S, Toffalori C, Punta M, Fetsch V, Wertheimer T, Rittmann MC, Braun LM, Follo M, Briere C, Vinnakota JM, Langenbach M, Koppers F, Shoumariyeh K, Engel H, Rückert T, Märklin M, Holzmayer S, Illert AL, Magon F, Andrieux G, Duquesne S, Pfeifer D, Staniek J, Rizzi M, Miething C, Köhler N, Duyster J, Menssen HD, Boerries M, Buescher JM, Cabezas-Wallscheid N, Blazar BR, Apostolova P, Vago L, Pearce EL, Becher B, Zeiser R. Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. Blood. 2022 Sep 8;140(10):1167-1181. doi: 10.1182/blood.2022016082.

Highlighted by this Editorial: Bleakley M, Biernacki M. MDM2 inhibition augments GVL effect. Blood. 2022 Sep 8;140(10):1064-1065. doi: 10.1182/blood.2022017724. PMID: 36074535.

Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti ME, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D, Cabezas-Wallscheid N. Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells. Nat Cell Biol. 2022 Jul;24(7):1038-1048. doi: 10.1038/s41556-022-00931-x. Epub 2022 Jun 20. 

Schönberger K, Mitterer M, Buescher JM, Cabezas-Wallscheid N. Targeted LC-MS/MS-based metabolomics and lipidomics on limited hematopoietic stem cell numbers. STAR Protoc. 2022 May 19;3(2):101408. doi: 10.1016/j.xpro.2022.101408.

Spohr C, Poggio T, Andrieux G, Schönberger K, Cabezas-Wallscheid N, Boerries M, Halbach S, Illert AL, Brummer T. Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo. Leukemia. 2022 Apr;36(4):970-982. doi: 10.1038/s41375-021-01490-0. Epub 2021 Dec 13.2021