Projects

Robert Zeiser

Targeting MDM2-induced p53 downregulation to enhance anti-leukaemia immunity

Florian Greten

Targetable modifiers of T cell exclusion in KrasG12D -driven colorectal cancer

Natalie Köhler

The role of oncogene-driven activation of the CMTM6 / PD-L1 axis in leukaemia immune escape

Lena Illert

The role of the NPM-ALK / PD-1 axis for immune response to T cell lymphoma

Nina Cabezas-Wallscheid
Katrin Kierdorf

Oncogene-driven adenosine production by leukaemic stem cells promotes their immune escape

Olaf Groß

Oncogene-driven inflammasome activity in myeloid neoplasms and its impact on leukaemia development and anti-cancer immunity

Marco Prinz

Modulation of the CNS innate immune system by the onco-metabolite (R)2-hydroxyglutarate in IDH1 mutant gliomas

Ian Frew

Manipulating STING signalling pathways in VHL mutant renal carcinoma cells to regulate T cell function

Mathias Heikenwälder
Maike Hofmann

Targeting the pro-oncogenic ER-stress mediator ATF6 to reset the immunosuppressive tissue-microenvironment in liver cancer

Justus Duyster

The role of oncogene induced Oncostatin M in reprogramming the stem cell niche and promoting immune escape of leukaemia

Alexander Nyström
Dimitra Kiritsi

The role of HRAS downstream signalling for the production of immunosuppressive metabolites in the microenvironment of HRAS-driven SCC

Tilman Brummer

Overcoming immune evasion of BRAF mutant colorectal cancer

Susana Minguet

Targeting oncogenic hubs of solid tumours to overcome immune evasion from adoptive T cell transfer

Miriam Erlacher
Bertram Bengsch

Understanding the crosstalk between juvenile myelomonocytic leukaemia (JMML) and immune cells

Dietrich Ruess

Targeting KRAS-driven tumours via their dependence on PTPN11/SHP2-phosphatase to enhance anti-tumour immunity

Melanie Börries
Anna Köttgen
Oliver Schilling

Data analysis, integration, and modelling

Wilfried Reichardt
Robert Zeiser

Preclinical Imaging and NMR Spectroscopy

Harald Binder

Information Infrastructure for Research Data Management

Robert Zeiser

Central tasks of the Collaborative Research Centre

Melanie Börries

Integrated Research Training Group (IRTG) for Oncogene-driven immune escape